This protocol demonstrates a method for producing quality control materials using porcine and goose blood, implying affordability for LMIC laboratories.
Commercial hematology internal quality control (IQC) materials are often costly, imported, and have limited shelf life, which poses a significant challenge for laboratories in low- and middle-income countries (LMICs). This protocol presents a low-cost, locally adaptable method for preparing IQC materials targeting white blood cell (WBC) parameters. Using porcine and goose blood sourced from legal commercial slaughterhouses, the samples are chemically fixed through a two-step stabilization process to preserve cellular morphology and WBC stability over 60 days. The method has been optimized for the Abbott Cell-Dyn Emerald 22 analyzer and validated across other platforms, including Sysmex and Horiba systems, making it applicable in diverse laboratory settings.
No takes yet. Share an insight, caveat, or question.
Vo et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: