This review highlights riboswitch dynamics influencing gene expression, suggesting new applications in synthetic biology.
Riboswitches are natural RNA regulatory elements that control gene expression through ligand-induced conformational changes. These dynamic RNA sensors modulate downstream gene activity by influencing transcription or translation. Recent advances in riboswitch engineering have expanded their utility in biotechnology and synthetic biology. This review highlights key insights into the structural and functional dynamics of riboswitches and discusses emerging strategies for their application as programmable biological tools.
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Chen et al. (2025) studied this question.
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