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August 17, 2025AntibodiesOpen Access

A Cancer-Specific Anti-Podocalyxin Monoclonal Antibody (humPcMab-60) Demonstrated Antitumor Efficacy in Pancreatic and Colorectal Cancer Xenograft Models

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Authors

HSHiroyuki SuzukiTohoku UniversityTOTomokazu OhishiMicrobial Chemistry Research FoundationTNTakuro NakamuraTokyo Medical University

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Implication

Anti-Podocalyxin monoclonal antibody humPcMab-60 demonstrates antitumor effects in pancreatic and colorectal cancer models, suggesting therapeutic potential.

Key Points

  • HumPcMab-60 exhibited significant antitumor effects against xenografts in mouse models of pancreatic and colorectal cancer.
  • In flow cytometry, humPcMab-60 specifically reacted with cancer cell lines, while sparing normal endothelial cells.
  • The engineered humanized monoclonal antibody displayed both antibody-dependent and complement-dependent cellular cytotoxicity against tumor cells.
  • This study highlights the potential of a cancer-specific monoclonal antibody as a promising targeted tumor therapy.

Cite This Study

Suzuki et al. (2025) studied this question.

synapsesocial.com/papers/68a36c1a0a429f797332f8d7https://doi.org/10.3390/antib14030067
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