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August 17, 2025Frontiers in MedicineOpen Access

The silent signals: emerging safety concerns in bispecific antibody therapy for multiple myeloma

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Authors

XZXiaoling ZhouUniversity of Electronic Science and Technology of ChinaELErdan LuoUniversity of Electronic Science and Technology of ChinaWCWei ChenUniversity of Electronic Science and Technology of China

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Implication

Analysis reveals significant safety signals in multiple myeloma therapies using teclistamab, talquetamab, and elranatamab, indicating important considerations for patient care.

Key Points

  • Safety signals varied among bispecific antibodies, with distinct adverse events associated with each treatment.
  • In total, 2,789,182 adverse event reports were retrieved, revealing significant associations in various disorder categories.
  • Analysis employed proportional reporting and reporting odds ratios to identify safety signals in the FAERS database.
  • Findings suggest novel safety signals that may inform clinical practice and treatment decisions for multiple myeloma.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68a36c210a429f797332f99ehttps://doi.org/10.3389/fmed.2025.1593405
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