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August 17, 2025GenesOpen Access

Alternative Splicing of Serum Response Factor Reveals Isoform-Specific Remodeling in Cardiac Diseases

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Authors

SASayed Aliul Hasan AbdiGAGohar AzharXZXiaomin Zhang

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Overview

Analysis reveals isoform-specific roles of serum response factor in cardiac diseases, suggesting biomarkers for heart failure.

Key Points

  • Extensive alternative splicing of serum response factor is linked to heart failure, impacting cardiac remodeling.
  • The predominant splicing type identified was skipped exon events, particularly at Exon 2 and Exon 5.
  • RNA-seq analysis used three cardiac condition databases, focusing on non-ischemic and ischemic cardiomyopathy.
  • Findings suggest regulatory interactions between serum response factor and key splicing factors in cardiac diseases.

Cite This Study

Abdi et al. (2025) studied this question.

synapsesocial.com/papers/68a36c210a429f797332fb38https://doi.org/10.3390/genes16080947
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