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This is a In Vitro Study study.

August 17, 2025Chemical ScienceOpen Access

Difluoromethylene Cyclobutyl Sulfonium Salts: Versatile Reagents for Chemodivergent Synthesis of Difluoroalkylated Cyclobutenes and Cyclobutanes

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The new difluoroalkylating reagent significantly improves the synthesis of difluoroalkylated compounds.
This report introduces cyclobutyl sulfonium salts as versatile reagents for effective synthesis.
An innovative approach enables chemodivergent synthesis of both cyclobutenes and cyclobutanes.
Implications include expanded methods for producing important fluorinated compounds in industry.

Implication

New difluoroalkylating reagent facilitates synthesis of difluoroalkylated cyclobutenes and cyclobutanes, suggesting industrial applications.

Abstract

Despite the significant applications of fluorinated cyclobutanes in industrial and diagnostic fields, efficient methods for synthesizing these valuable fluorinated structures remain limited. Here, we report a new difluoroalkylating reagent, 2-(difluoromethylene)cyclobutyl...

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Cite This Study

Feng et al. (2025) studied this question.

synapsesocial.com/papers/68a36c360a429f7973330558 https://doi.org/10.1039/d5sc05409e

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Implication

New difluoroalkylating reagent facilitates synthesis of difluoroalkylated cyclobutenes and cyclobutanes, suggesting industrial applications.

Difluoromethylene Cyclobutyl Sulfonium Salts: Versatile Reagents for Chemodivergent Synthesis of Difluoroalkylated Cyclobutenes and Cyclobutanes

Key Points

Implication

Abstract

Discussion

Cite This Study

Difluoromethylene Cyclobutyl Sulfonium Salts: Versatile Reagents for Chemodivergent Synthesis of Difluoroalkylated Cyclobutenes and Cyclobutanes

Key Points

Implication

Abstract

Discussion

Cite This Study

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