Review highlights effective geroprotectors like antioxidants and enzyme mimetics for health benefits related to aging.
Aging is an inevitable stage of life, a natural process that we all experience and often strive to slow down. As life expectancy on Earth continues to rise, the quest for longevity and vitality becomes increasingly significant. However, alongside this increase in lifespan, we face the emergence of diseases associated with aging and genetic mutations that can lead to various health complications. This dual challenge has long been a concern for researchers and healthcare professionals. To mitigate the negative impact of aging on health, it is crucial to explore ways to slow down this process. This article discusses several promising options that suggest their effectiveness against aging, potentially acting as geroprotectors. Among these, antioxidants are perhaps the most popular choice due to their ability to reduce oxidative stress caused by free radicals—unstable molecules that can damage cells and contribute to aging. In addition to traditional antioxidants, synthetic antioxidants such as enzyme mimetics are becoming a focal point of therapeutic research. These compounds aim to replicate the action of natural enzymes that combat oxidative stress, offering a novel approach to age-related health issues. Furthermore, polyphenols, naturally occurring compounds found in various fruits, vegetables, and beverages like tea and red wine, have garnered attention for their potential health benefits. Together, these compounds may contribute to new research opportunities aimed at combating age-related pathology and improving overall health outcomes. By understanding and harnessing the power of antioxidants, enzyme mimetics, and polyphenols, we may pave the way for innovative interventions that not only extend lifespan but also enhance the quality of life for individuals as they age. The pursuit of effective geroprotectors represents a vital frontier in promoting healthy aging and preventing age-related diseases.
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Shulgau et al. (2025) studied this question.
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