What type of study is this?

This is a In Vitro Study study (also classified as: Observational).

August 17, 2025

Integrative Multiomic and Deep Learning Profiling of KRAS Mutant and Wildtype Genomes in Pancreatic Tumorigenesis

View Full Paper

Ask AI

Bookmark

Authors

ZAZarlish AttiqueQuaid-i-Azam University HAHafiz Muhammad Faraz AzharQuaid-i-Azam University AAAdnan Ahmed AnsariQuaid-i-Azam University

Discussion

Member takes

Implication

Integrative analysis reveals shared transcriptional programs in KRAS-mutant and wild-type pancreatic tumors, highlighting potential therapeutic targets.

Key Points

KRAS-mutant and wild-type pancreatic tumors converge on shared malignancy-promoting mechanisms, which could enhance treatment strategies.
The deep learning model achieved an AUC of 0.94, effectively stratifying tumors and correlating with patient survival.
Multiomic integration illustrated hyperactive effectors like TFAP2A and CARTPT that significantly influence tumor behavior.
Network analysis identified CAV1 as a key hub in therapy resistance, displaying expression in both lung and liver metastases.

Cite This Study

Attique et al. (2025) studied this question.

synapsesocial.com/papers/68a36dd20a429f7973330a6b https://doi.org/10.21203/rs.3.rs-7335783/v1

View Full Paper

Ask AI

Bookmark

Implication

Integrative analysis reveals shared transcriptional programs in KRAS-mutant and wild-type pancreatic tumors, highlighting potential therapeutic targets.

Integrative Multiomic and Deep Learning Profiling of KRAS Mutant and Wildtype Genomes in Pancreatic Tumorigenesis

Discussion

Member takes

Implication

Key Points

Cite This Study

Integrative Multiomic and Deep Learning Profiling of KRAS Mutant and Wildtype Genomes in Pancreatic Tumorigenesis

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider