Observational analysis shows no significant difference in systemic immune inflammation markers in children with adenoid hypertrophy, indicating inflammation may not correlate with airway obstruction.
Objectives: This study aims to evaluate the effect of adenoid or adenotonsillar hypertrophy, which causes sleep apnea, on the systemic immune inflammation index (SII). Patients and Methods: The study group consisted of 83 patients (46 males, 37 females; mean age: 7.4±2.4 year; range, 3-17 year) who underwent adenoidectomy or tonsillectomy due to obstruction at the Department of Otolaryngology, Malatya Training and Research Hospital, between January 2024 and July 2024. A control group was formed from 75 healthy children (46 males, 29 females; mean age: 8.0±3.4 year; range, 3-17 year). The medical records of the patients were reviewed retrospectively, and the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and SII (calculated as neutrophil count × platelet count / lymphocyte count) were obtained from complete blood count data and compared. Results: The study group had a NLR of 1.31±0.72, while the control group had an NLR of 1.39±0.76. The PLR was 112.34±37.06 in the study group and 110.29±38.55 in the control group. The study group had a SII of 502.03±310.09, while the control group had a SII of 428±234.08. No statistically significant differences were found between the study and control groups regarding the median values of NLR, PLR, and SII (p>0.05). Conclusion: The findings indicate that NLR, PLR, and SII, often used as markers of inflammation in various diseases, do not correlate with upper airway obstruction.
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Pınar Tekin (2025) studied this question.
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