Biopsy-Proven Solid Organ Transplant Graft-Versus-Host Disease (SOT-GVHD) Involving the Skin, Liver, and Bone Marrow in a Simultaneous Kidney-Pancreas Transplant Recipient
Case report highlights complications of graft-versus-host disease in a kidney-pancreas transplant recipient, suggesting enhanced monitoring is essential.
Key Points
Graft-versus-host disease developed post-transplant, leading to severe complications and prolonging ICU stay.
Skin biopsy showed interface vacuolar dermatitis, and bone marrow assays revealed 43% donor-origin T-cells.
Assessment included multiple biopsies and a microchimerism assay to diagnose the condition accurately.
Prompt recognition of SOT-GVHD may improve management strategies and patient outcomes.