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August 17, 2025

Correlation between MGMT methylation and the efficacy of bevacizumab in high-grade glioma

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Observational analysis shows improved overall survival in methylated MGMT groups treated with bevacizumab, indicating biomarker importance.

Methylated MGMT group experienced higher overall survival and progression-free survival after bevacizumab treatment, compared to unmethylated.
Overall survival was significantly better in patients with methylated MGMT, with a notable increase in tumor control rates observed.
COX regression analysis identified significant factors affecting progression-free and overall survival, with the influence of tumor resection noted.
The findings support the potential of MGMT methylation as a biomarker for bevacizumab efficacy in high-grade glioma patients.

Yan et al. (2025) studied this question.

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Observational analysis shows improved overall survival in methylated MGMT groups treated with bevacizumab, indicating biomarker importance.