What question did this study set out to answer?

To compare a 3D volumetric approach against accepted 1D, 2D, and geometric 3D surrogate measurements for assessing posttreatment response in pituitary adenomas.

July 2, 2019Journal of the Endocrine SocietyOpen Access

Comparison of Radiographic Approaches to Assess Treatment Response in Pituitary Adenomas: Is RECIST or RANO Good Enough?

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Authors

BIBrandon S. ImberMemorial Sloan Kettering Cancer Center ALAndrew LinMemorial Sloan Kettering Cancer Center ZZZhigang ZhangMemorial Sloan Kettering Cancer Center

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Implication

Retrospective study finds standard 1D and 2D criteria correlate adequately with 3D volumetrics in pituitary adenomas, indicating routine RECIST and RANO measurements remain clinically sufficient.

Key Points

To compare a 3D volumetric approach against accepted 1D, 2D, and geometric 3D surrogate measurements for assessing posttreatment response in pituitary adenomas.
Retrospectively evaluated 34 patients (median age 50 years; 50% male) with pituitary adenomas who received sellar radiotherapy at a tertiary cancer center.
Measured tumor dimensions using 1D RECIST, 2D RANO, and geometric 3D spherical/ellipsoid models, and compared them against manual 3D volumetric segmentation and Hakon Wadell sphericity calculations.
Tumors exhibited mean sphericity of 0.63 pre-radiotherapy and 0.60 post-radiotherapy, with the majority of patients categorized as having stable disease across all assessment methods.
Posttreatment response for 1D, 2D, and 3D spherical assessments correlated moderately well with 3D volumetrics (1D correlation: r = 0.66, P < 0.0001; intraclass correlation reliability P < 0.001), outperforming 3D ellipsoid models (P = 0.009).
Manual 3D volumetric measurements identified a higher number of partially responding and progressive lesions compared with 1D and 2D surrogate methods.

Cite This Study

Imber et al. (2019) studied this question.

synapsesocial.com/papers/6a7a4fd25968508e56f3bcad https://doi.org/10.1210/js.2019-00130

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Implication

Retrospective study finds standard 1D and 2D criteria correlate adequately with 3D volumetrics in pituitary adenomas, indicating routine RECIST and RANO measurements remain clinically sufficient.

Comparison of Radiographic Approaches to Assess Treatment Response in Pituitary Adenomas: Is RECIST or RANO Good Enough?

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of Radiographic Approaches to Assess Treatment Response in Pituitary Adenomas: Is RECIST or RANO Good Enough?

Discussion

Member takes

Implication

Key Points

Cite This Study

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