Comparing Volumetric to 2D Methods in Assessing Post-treatment Response of Different Pediatric Low-Grade Glioma (pLGG) Tumor Components

This is the authors' abstract. We don't add key points for this paper.

Accurate response assessment is critical in pediatric low-grade glioma (pLGG) as there is significant morbidity associated with continued treatment. Current standards for assessment rely on 2D measurements. Given the heterogenous nature of pLGG, volumetric assessment of treatment response may prove more effective. In this study, we compared 2D and volumetric methods of assessing treatment response in patients from the PNOC-002 clinical trial of pLGG. We analyzed the quantitative differences between 2D and volumetric measurements of tumor volume percent change post-treatment. We also compared classification of treatment response based on application of RANO criteria to various pLGG tumor components.