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August 17, 2025Open Access

Nanocarrier Strategies for Deep Tumour Penetration

VBValentin A. BobrinThe University of Queensland JZJinbo ZhangCapital Medical University GWGordon D. WuHarvard University

Key Points

Deep tumour penetration of nanocarriers faces significant barriers, limiting treatment efficacy.
Overcoming physiological barriers and the tumour microenvironment is crucial for successful delivery.
This review analyzes various nanocarrier strategies to enhance delivery deep into solid tumours.
Improving nanocarrier design may increase drug effectiveness, supporting cancer nanomedicine initiatives.

Abstract

Deep penetration of nanocarriers into solid tumours remains a major challenge in cancer nanomedicine due to the complex tumour microenvironment (TME) and associated physiological barriers. This review examines nanocarrier strategies...

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