Primary Sclerosing Cholangitis in a Patient with Overlapping Autoimmune Liver Diseases: A Radiologic Case Report

Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic liver disease characterized by inflammation and fibrosis of the intrahepatic and extrahepatic bile ducts, leading to multifocal strictures and dilatations. We report the case of a [age]-year-old [male/female] patient presenting with [symptoms: e.g., pruritus, fatigue, jaundice]. Laboratory investigations revealed cholestatic liver enzyme abnormalities, while magnetic resonance cholangiopancreatography (MRCP) demonstrated irregular narrowing and segmental dilatations of the biliary tree, consistent with the “beading” pattern typical of PSC. The patient had no history of secondary causes of sclerosing cholangitis. Additional workup revealed [optional: association with inflammatory bowel disease, abnormal serology, etc.]. Based on clinical, laboratory, and imaging findings, a diagnosis of PSC was established. The patient was managed with [medical treatment, symptomatic care, or liver transplantation evaluation]. This case highlights the importance of recognizing the characteristic radiologic features of PSC for early diagnosis and management to prevent disease progression and its complications.