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August 17, 2025East Africa Science

Inadequate Clearance of Circulating Cathodic Antigen Following Single-Dose Praziquantel Treatment Among Pre- and School-Aged Children in Schistosoma mansoni Hyper-Endemic Areas of North-Western Tanzania

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Authors

MZMholya F. ZabronCatholic University of Health and Allied SciencesNJNyanda C. JustineCatholic University of Health and Allied SciencesMZMaria ZingaCatholic University of Health and Allied Sciences

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Overview

Longitudinal study finds poor clearance of circulating cathodic antigen in children with schistosomiasis, suggesting need for better diagnostic methods.

Key Points

  • Praziquantel shows varied efficacy, with a parasitological cure rate of 66.3% based on Kato-Katz results, but only 27.6% when assessed using POC-CCA.
  • Of the 161 children tested, 70% were infected with S. mansoni, with a significant discrepancy in results between Kato-Katz and POC-CCA methods.
  • The study emphasizes the limitations of traditional diagnostics, pointing to the need for improved monitoring strategies in schistosomiasis control efforts.
  • Cure rates differed significantly underlining a critical gap in assessing treatment success, especially concerning circulating cathodic antigen.

Cite This Study

Zabron et al. (2025) studied this question.

synapsesocial.com/papers/68a36dec0a429f7973331b35https://doi.org/10.24248/easci.v7i1.120
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Point-of-care circulating cathodic antigen positivity and associated factors in school children one year after mass praziquantel administration in an endemic district in Ghana2024
  2. 2Efficacy and safety of prazequantel for the treatment of Schistosoma mansoni infection across different transmission settings in Amhara Regional State, northwest Ethiopia2024 · 6 citations
  3. 3Diagnostic Performance and Discordance of Kato–Katz Method, POC-CCA Test, and PCR in Detecting Schistosoma mansoni in a Low-Prevalence South African Setting2026
  4. 4Kato-Katz versus Urine Circulating Cathodic Antigen for the Diagnosis of Schistosoma mansoni in Preschool- aged children in Homabay County- Kenya2024
  5. 5Individual and spatial heterogeneity of praziquantel efficacy against Schistosoma mansoni within the context of repeated mass drug administration2026