What type of study is this?

This is a Literature Review study (also classified as: Animal Study).

August 17, 2025BiomoleculesOpen Access

Valence-Driven Cognitive Flexibility: Neurochemical and Circuit-Level Insights from Animal Models and Their Relevance to Schizophrenia

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Review highlights distinct neural circuits for cognitive flexibility in schizophrenia, indicating the roles of dopamine and serotonin.

Significant cognitive inflexibility observed in schizophrenia affects disease progression and treatment outcomes.
Aversive tasks primarily engage the hippocampal–medial prefrontal cortex pathway, contrasting with appetitive tasks.
Neural mechanisms in rodent models provide insights into the differential roles of neurotransmitters like dopamine and serotonin.
The study framework clarifies literature inconsistencies and emphasizes motivational context in cognitive processes.

Asraf et al. (2025) studied this question.

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