Cy-Tb test enhances detection of latent tuberculosis infection among high-risk groups, suggesting potential for TB elimination.
Latent Tuberculosis Infection (LTBI) is a sustained immune response to Mycobacterium tuberculosis without clinical evidence of active disease, representing a substantial reservoir, contributes to the global burden of tuberculosis (TB). To address these gaps, Cy-Tb test (formerly C-Tb), developed by the Serum Institute of India, Pune, has been introduced under NTEP policy, combines the operational simplicity of TST with the specificity of IGRAs, expanded the coverage of high-risk groups and household contacts of pulmonary TB patients. Cy-Tb represents a next-generation LTBI diagnostic solution that supports early detection, operational alignment with point-of-care testing, cost-effectiveness, integration potential into national programs and contributes significantly towards the goal of TB elimination in India by 2025 and globally by 2035.
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Bharti et al. (2025) studied this question.
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