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This is a In Vitro Study study.

August 17, 2025Catalysis Science & Technology

Well-defined Zn(II) catalysts for sustainable synthesis of pharmaceutically relevant bis(indolyl)methanes via the activation of aromatic and aliphatic alcohols

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The use of zinc(II) catalysts successfully enabled the activation of primary alcohols as alkylating agents.
Synthesis of bis(indolyl)methanes was performed with a focus on utilizing environmentally friendly methods.
Phosphine-free NNN-type bis(iminopyridine) complexes were developed to support the reaction efficiency and selectivity.
Findings highlight the potential for scaling this method to produce pharmaceuticals sustainably.

Implication

This study demonstrates synthesis of bis(indolyl)methanes using zinc catalysts, suggesting a new method for pharmaceutical applications.

Abstract

This study presents the synthesis of pharmaceutically important bis(indolyl)methanes (BIMs) via the activation of primary alcohols serving as alkylating agents, enabled by zinc(II) complexes. Two phosphine-free NNN-type bis(iminopyridine) pincer innocent...

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Cite This Study

Chauhan et al. (2025) studied this question.

synapsesocial.com/papers/68a36f8a0a429f79733325a6 https://doi.org/10.1039/d5cy00765h

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Implication

This study demonstrates synthesis of bis(indolyl)methanes using zinc catalysts, suggesting a new method for pharmaceutical applications.

Well-defined Zn(II) catalysts for sustainable synthesis of pharmaceutically relevant bis(indolyl)methanes via the activation of aromatic and aliphatic alcohols

Key Points

Implication

Abstract

Discussion

Cite This Study

Well-defined Zn(II) catalysts for sustainable synthesis of pharmaceutically relevant bis(indolyl)methanes via the activation of aromatic and aliphatic alcohols

Key Points

Implication

Abstract

Discussion

Cite This Study

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