Bicelle-induced skin penetration mechanism for hydrophilic molecules

Q: What type of study is this?

This is a In Vitro Study study.

Yusuke Hayashida; K. Ohata; Liliana de Campo; Mina Tanigawa; Noriko Miyamoto; Takuya Matsunaga; Mina Sakuragi

doi:10.1039/d5ra05449d

January 1, 2025RSC AdvancesOpen Access

Bicelle-induced skin penetration mechanism for hydrophilic molecules

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Key Points

Bicelles enhance transdermal delivery of hydrophilic molecules and high-molecular-weight compounds.
The study demonstrates bicelles' ability to form water-containing structures within the stratum corneum.
Assessment of bicelle structures indicates potential for improved drug delivery systems.
This finding highlights the strategic importance of bicelles in transdermal therapies.

Implication

Observational analysis reveals bicelles improve transdermal delivery of hydrophilic compounds, suggesting new delivery methods.

Abstract

We demonstrated that the disk-shaped structures, bicelles, composed of phospholipids enhance the transdermal delivery of hydrophilic and high-molecular-weight compounds by forming water-containing lamellar structures within the stratum corneum (SC).

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Cite This Study

Hayashida et al. (2025) studied this question.

synapsesocial.com/papers/68a36f8a0a429f79733326bf https://doi.org/10.1039/d5ra05449d

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Bicelle-induced skin penetration mechanism for hydrophilic molecules

Key Points

Implication

Abstract

Discussion

Cite This Study

Bicelle-induced skin penetration mechanism for hydrophilic molecules

Key Points

Implication

Abstract

Discussion

Cite This Study

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