Comparison of Lipid Profile in Type-II Diabetes Patients on Insulin Vs Oral Hypoglycemic Agents

Objective: To compare parameters of lipid profile in type-II diabetic patients managed with Insulin and Oral hypoglycemic agents (OHAs) at Pak Emirates Military Hospital (PEMH, RWP) Methodology: A comparative cross-sectional study was conducted over a period of nine months after ethical approval from July 2021 to April 2022.Written informed consent from the potential participants was taken using a non-probability convenient sampling technique on patients suffering from type-II Diabetes Mellitus (DM) and managed with either OHAs or insulin for more than one year were studied at Medicine department (PEMH, RWP). Serum lipid profile was carried out on all the study participants with good control of diabetes at the time of enrollment in the study. Comparison of various lipid profile parameters were done in both the study groups. Results: Out of 550 patients included in the final analysis 300 (54.5%) were male and 250 (45.5%) were female. Mean age of the patients suffering from DM included in the study was 46.54±4.62 years. There were 205 (37.3%) patients with hypercholesterolemia while 181 (32.9%) patients had hypertriglyceridemia. The incidence of hypercholesterolemia and hypertriglyceridemia was statistically significantly high in patients managed with OHAs as compared to those who were managed with insulin (p-value<0.001). Conclusion: Serum triglycerides and serum total cholesterol were found more significantly within range in patients who were managed with insulin as compared to those who were managed by OHAs. Deranged HDL and LDL levels were not significantly different in both groups.