Correlation of Osteocalcin and Fetuin-A levels with Renal Function and Other Biomarkers in CKD patients from Baghdad

Background: This investigation aims to determine if a correlation existed between the levels of Osteocalcin, Fetuin-A, and other biochemical markers in patients with CKD compared to healthy.Methods: One hundred eighty samples divided into 120 (CKD) patients in end-stage divided into 70 males and 50 females, and 60 healthy controls 35 males and 25 females were taken between November 2022 and March 2023 from three major hospitals in Baghdad. diagnosed using symptoms, biochemical testing, history, and clinical examination by specialized nephrologists. Urea, creatinine, calcium, albumin, and phosphate were measured by spectrophotometer (Roche Cobas C111). Furthermore, a spectrophotometer (Beckman coulter au480) was used to measure sodium and potassium levels. On the other hand, vitamin D3 level and PTH were measured by spectrophotometer (Roche Cobas E411). Moreover, Osteocalcin and Fetuin-A were done by ELISA technique.Results: The present study found that the male patients are more than females, and the highest percentage of CKD cases were found in the age group of 50-59 years. also, indicates a strong positive correlation between the levels of Fetuin-A and GFR. while a strong negative correlation between the levels of Fetuin-A with creatinine, urea, and Osteocalcin, moreover, a strong negative correlation between the level of Osteocalcin with GFR and Fetuin-A. The study also found a strong positive correlation between the levels of Osteocalcin with urea and creatinine.Conclusion: Decreased Fetuin-A concentrations have been linked to increased calcification in the vasculature and mortality, increased Osteocalcin levels in CKD may not confer a protective effect against bone disorders.