Laboratory investigation reveals aluminum oxide nanoparticles significantly inhibit Staphylococcus aureus, suggesting potential for infection control.
Background: Staphylococcus aureus, which is known as the most significant nosocomial pathogen and frequently causes postoperative wound infections, is a serious health issue in hospitals. Staphylococcus aureus has become increasingly drug resistant, and most of its strains have been shown to be resistant to practically all antibiotics. Numerous medical applications of aluminum oxide have been investigated, and this research indicates that the growth of Staphylococcus aureus may be inhibited in the presence of aluminum oxide nanoparticles.Methods: The study was conducted from March 2023 to the end of July 2023 at Al-Aziziya Hospital in Iraq. Using spectrophotometry on microtiter plates, biofilms were created in vitro. Single isolated organisms of Staphylococcus aureus were examined for antibiotic susceptibility patterns using a conventional disk diffusion method. Furthermore, Prepared aluminum oxide nanoparticles were characterized using various techniques.Results: The results show that strongly inhibited growth of Staphylococcus aureus in the presence of aluminum oxide nanoparticles after 24 hours at 0.06125,0.1225 0.245, and 0.49 M. On the other hand, X-ray diffraction analysis revealed an average crystallite size of 35 nm for the aluminum oxide nanoparticles. The FT-IR spectrum displayed prominent peaks at 615 and 636, corresponding to the stretching vibrations of aluminum oxide. The EDX measurements confirmed the presence of aluminum (Al) and oxygen (O) peaks, indicating the purity of the sample.Conclusions: The antimicrobial assay demonstrated that the aluminum oxide nanoparticles exhibited significant antibacterial activity against Staphylococcus aureus. At a concentration of 0.06125 M of Al2O3, Staphylococcus aureus displayed a maximum zone of inhibition measuring 39 mm.Keywords: Aluminum oxide nanoparticles; Green synthesis; Pomegranate leaves; Staphylococcus aureus bacteriaEditorial Expression of Concern20 June 2025: Following publication of this paper, the internal audit (consequent to concerns on quality raised by Web of Science) notified Advancements in Life Sciences about problems in use of English language. By this Editorial Expression of Concern, we alert the scientific community as we address the errors.Editorial Note26 June 2025: You are viewing the latest version of this article having minor corrections related to the use of English language. Expression of concern is hereby revoked.
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