Understanding the differential diagnosis of Acute Undifferentiated Febrile Illness in a health care setting: A critical review

Acute onset of fever, chills, myalgia, and fatigue are common features of many infections that are endemic in India. In many areas of developing countries, where diagnostic facilities are limited, etiologies of acute undifferentiated febrile illness (AUFI) remain largely unknown. Physicians often diagnose patients presumptively based on clinical features and assumptions regarding circulating pathogens. These AUFI that includes scrub typhus, dengue fever, malaria, enteric fever, and leptospirosis among others cause significant mortality and morbidity. Through this article we wish to focus on the differential diagnosis of Acute Undifferentiated Febrile Illness.