Personalized Approaches to Pharmacotherapy and Physiotherapy in Obstetric Treatment: Improving Medication Safety and Physical Wellness for Pregnant Women

Individualized pharmacology and physical therapy are two areas that have the potential to revolutionize obstetric care, providing evidence-based therapies that will have improved maternal and fetal health outcomes. Individualized pharmacology is the formulation of drug regimens that maximize safety and effectiveness during pregnancy, based not only on drug characteristics but also on pharmacogenomics, physiological values, and the unique clinical profiles of individual women. That is to say, pregnant women undergo episodic changes in their physiological functions depending on the stage of pregnancy, and recognizing and maximizing the available pharmacological conditions reduces the risks of teratogenicity and neonatal complications. Physical therapy can have similar benefits targeting generalized musculoskeletal pains, such as pelvic girdle pain and low back pain, while also optimizing mobility to prevent other complications, including gestational diabetes and preeclampsia. Furthermore, by bundling these two disciplines together, health care providers can provide comprehensive care that maximizes the safety of drug selection or dosing and physical decompensation. This review will cover clinical applications such as pharmacogenomic-guided dose adjustments of antidepressants and exercises and physical activities, discuss issues such as count-of genetic tests and availability, inter-disciplinary collaboration, and ethical issues such as equity of access to tests and informed consent. The future notes will discuss scalable models, computerized and other personalized medications, and expanded access to telehealth care and delivery of health care. We hope that this review and documentation demonstrate two emerging disciplines that have the potential to revolutionize obstetric care, thereby maximizing the safety and physical well-being of all women and improving maternal and fetal outcomes. drug safety, perinatal care, personalized pharmacotherapy, physical therapy, health of women