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August 21, 2025PLoS ONEOpen Access

The role of SLC2A1 in lung adenocarcinoma: From tumorigenesis to patient survival

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Authors

ZXZijun XiaoEngineering Systems (United States)QLQinqin LongAffiliated Hospital of Youjiang Medical University for NationalitiesJLJiali LiaoSun Yat-sen University

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Implication

Systematic assessment shows SLC2A1 influences tumor growth and immune response in lung adenocarcinoma, suggesting its use as a biomarker.

Key Points

  • SLC2A1 expression negatively correlates with DNA methylation in lung adenocarcinoma, highlighting its role in tumorigenesis.
  • ROC analysis indicates SLC2A1 serves as a reliable prognostic biomarker for lung adenocarcinoma outcomes.
  • In vitro and in vivo studies reveal that SLC2A1 inhibition reduces proliferation, migration, and invasion in lung adenocarcinoma cells.
  • The findings underline the importance of SLC2A1 in immune regulation and its potential therapeutic implications in lung adenocarcinoma.

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/68a6fb925502675167ba8e7ehttps://doi.org/10.1371/journal.pone.0324043
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