Fetuin-A is a predictor of mortality in organophosphate poisoning

Organophosphate (OP) poisoning is a serious health problem that causes morbidity and mortality in developing countries. It is important to determine biomarkers and exposures to diagnose organophosphate poisoning. Fetuin-A is a negative, acute-phase reactant. We aimed to investigate whether fetuin-A could be used to predict mortality in organophosphate poisoning. Consecutive patients aged > 18 years who were admitted to the emergency department were included in this study. Fetuin-A and pseudocholinesterase levels, hemograms, and biochemical blood parameters of patients were documented. Patients were divided into 2 groups: survivors (group 1) and those who died (group 2) due to organophosphate poisoning. Chi-square test and Mann-Whitney U test were used to compare the 2 groups. To determine the factors affecting mortality, the statistically significant parameters determined in the univariate analysis were included in the multivariate logistic regression risk model. Statistical significance was set at P < .05. The mean age of all cases was 38.05 ± 11.29 years, and 88 (40.5%) were female. The serum fetuin-A, pseudocholinesterase, and lactate levels of patients in Group I were 148.03 ± 18.93 ng/mL, 5184.58 ± 1793.41 U/L, and 2.84 ± 1.26 mmol/L, respectively. Whereas, in Group 2, these values were 101.91 ± 5.29 ng/mL, 1034.06 ± 59.66 U/L, and 6.96 ± 0.56 mmol/L, respectively (P < .001). However, in logistic regression analysis, fetuin-A, lipase, and lactate were identified as prognostic markers. The specificity and sensitivity of fetuin-A, lipase, and lactate levels were high in ROC curve analysis. Fetuin-A is a potential prognostic marker for organophosphate poisoning.