August 16, 2025Cell Death and DiseaseOpen Access

Arginyltransferase1 drives a mitochondria-dependent program to induce cell death

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Research reveals arginyltransferase1 links oxidative stress and mitochondrial pathways to regulate cell death mechanisms.

Arginyltransferase1 induces cell death through mitochondrial mechanisms, highlighting its dual roles.
The study shows that Ate1's mitochondrial translocation is essential for triggering apoptosis during oxidative stress.
Using budding yeast as a model, evidence reveals that Ate1-induced cell death is influenced by the mitochondrial permeability transition pore.
Contrary to previous beliefs, cytosolic protein degradation pathways have negligible effects on Ate1-induced cell death.

Kumar et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark