Case report highlights key clinical features of primary hypertrophic osteoarthropathy in a teenager, suggesting early diagnosis is vital.
Primary hypertrophic osteoarthropathy(PHO), characterised by digital clubbing, periostosis, pachydermia, and hyperhidrosis, is also known as pachydermoperiostosis (PDP). It isa rare genetic conditionwith three clinicalpresentations. Here,we describe a 14-year-old boy presenting with recurrent episodes of arthralgia, profuse perspiration, and increasing swelling of his fingers and toes. On examination, all digits exhibitedgrade 4 clubbing, hyperhidrosis, and anemia. Secondary causes of clubbing and hyperhidrosiswere excluded. Although the clinical characteristics met the requirements for PDP, genetic testing was not carried out because of monetary limitations. Male preponderance and varying inheritance patterns characterize PDP, which usually first appears in adolescence, develops over ten years, and stabilizes. Thyroid acropathyand acromegaly are few of manydifferential diagnoses. This instance emphasizes how critical it is to conduct a comprehensive assessment and identify PDP early, especially in situations when genetic testing is not available.
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Shouri et al. (2025) studied this question.
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