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This is a Systematic Review study.

Saliva Based Clozapine Therapeutic Drug Monitoring: A Systematic Review

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Saliva collection for clozapine TDM offers simplicity and less invasiveness compared to blood draws.
Clozapine levels in saliva showed a range between 8.50 ng/mL and 2,720 ng/mL, with stability for six months at -20°C.
A systematic review analyzed various detection methods, but no correlation with blood levels was established overall.
Further clinical validation is necessary before saliva can replace blood for clozapine monitoring.

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Systematic review evaluates saliva for clozapine therapeutic drug monitoring, suggesting potential benefits over blood tests.

Rademaker et al. (2025) studied this question.

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