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August 18, 2025mBioOpen Access

The intracellular agent of Q fever, Coxiella burnetii , alters human alveolar macrophage metabolism and mitochondrial physiology

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Authors

HAHet AdhvaryuUniversity of Arkansas for Medical SciencesLHLu HuangJiangnan UniversityCLCarrie M. LongNational Institute of Allergy and Infectious Diseases

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Implication

Observational analysis shows C. burnetii manipulates macrophage metabolism to support its growth, highlighting the role of oxidative phosphorylation.

Key Points

  • Coxiella burnetii alters host oxidative phosphorylation during infection, maintaining a pro-bacterial environment within macrophages.
  • Inhibition of oxidative phosphorylation impairs the expansion of the Coxiella-containing vacuole, crucial for bacterial replication.
  • The study used primary human alveolar macrophages to investigate the metabolic modulation during infection by C. burnetii.
  • Understanding these mechanisms may guide future therapeutic strategies against infections caused by this pathogen.

Cite This Study

Adhvaryu et al. (2025) studied this question.

synapsesocial.com/papers/68af4314ad7bf08b1ead186ehttps://doi.org/10.1128/mbio.01436-25
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