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August 18, 2025Medical SciencesOpen Access

Combined Use of Vitamin D and DPP-4 Inhibitors as a Potential Adjuvant Treatment Strategy to Enhance the Efficacy of Novel Beta-Cell Replacement Therapies for Type 1 Diabetes

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VIDPP-4i combination therapy may enhance beta-cell function and survival in type 1 diabetes patients.
Emerging evidence suggests that vitamin D and DPP-4 inhibitors work together to promote long-term graft viability.
This narrative review analyzes mechanisms through which VIDPP-4i therapy may mitigate factors affecting replacement therapies.
Findings underscore the potential of synergistic treatments to improve outcomes for patients undergoing beta-cell replacement.

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Narrative review discusses how VIDPP-4i combination therapy may improve beta-cell function, highlighting immune and metabolic mechanisms.

Pinheiro et al. (2025) studied this question.

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