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August 1, 2025Journal of Cosmetic DermatologyOpen Access

Efficacy and Safety of Oral Spironolactone for Women With Acne Vulgaris: A Systematic Review and Meta‐Analysis of Randomized Placebo‐Controlled Trials With Trial Sequential Analysis

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Authors

LGLaura GhanemNKNigar KirmaniNFNathalia de León Fernández

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Overview

Systematic review and meta-analysis highlights effectiveness of spironolactone for acne treatment in women, indicating potential as standard care.

Key Points

  • Oral spironolactone significantly improves acne compared to placebo, enhancing treatment options.
  • Objective assessment showed an odds ratio of 6.59 for acne improvement with spironolactone.
  • This systematic review included 563 female patients across 5 randomized controlled trials, confirming its efficacy.
  • Spironolactone was found safe with no significant increase in menstrual irregularities or breast enlargement.

Cite This Study

Ghanem et al. (2025) studied this question.

synapsesocial.com/papers/68af431bad7bf08b1ead1c53https://doi.org/10.1111/jocd.70411
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study2024 · 29 citations
  2. 2Low Usefulness of Potassium Monitoring Among Healthy Young Women Taking Spironolactone for Acne2015 · 127 citations
  3. 3Adult female acne: a guide to clinical practice2019 · 172 citations
  4. 4A global perspective on the epidemiology of acne2015 · 784 citations
  5. 5The efficacy of Topical Clascoterone versus systematic spironolactone for treatment of acne vulgaris: A systematic review and network meta-analysis2024 · 9 citations