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August 18, 2025JOR SpineOpen Access

Biological Sex Is Under‐Reported in Cartilage‐Related Preclinical Research: A Cross‐Sectional Analysis

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Cross-sectional analysis reveals significant sex bias in OA and IDD research, suggesting the need for improved guidelines.

Only 61.9% of the 284 studies reported biological sex, raising concerns about sex bias.
Among studies reporting sex, 56% used samples primarily from male donors, limiting research applicability.
The cross-sectional study evaluated journals' adherence to sex reporting requirements in OA and IDD research.
Failure to report donor sex in 37.7% of applicable papers highlights potential translational issues in research.

Zuncheddu et al. (2025) studied this question.

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