A mitochondria-targeted near-infrared fluorescent probe for detecting H₂S, Cys, and GSH simultaneously in tumors

Miaomiao Zhang; Ying Yang; Zijuan Hai; Shusheng Zhang; Bin Zhao

doi:10.1039/d5cc03593g

January 1, 2025Chemical Communications

A mitochondria-targeted near-infrared fluorescent probe for detecting H₂S, Cys, and GSH simultaneously in tumors

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Key Points

The fluorescent probe effectively detects multiple biomarkers in tumors, enhancing diagnostic capabilities.
Key evidence shows it can identify H2S, Cys, and GSH simultaneously in vitro and in vivo.
This approach uses a mitochondria-targeted design to improve the specificity of detection in tumor tissues.
This may enable more accurate tumor identification, but broader clinical validation is needed.

Implication

Observational analysis demonstrates simultaneous detection of H2S, Cys, and GSH in tumors, suggesting its potential in cancer diagnostics.

Abstract

In this study, we developed a mitochondria-targeted near-infrared fluorescent probe HD-Br-D for simultaneous detection of H 2 S, Cys, and GSH in vitro and in vivo .

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af4322ad7bf08b1ead2006 https://doi.org/10.1039/d5cc03593g

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A mitochondria-targeted near-infrared fluorescent probe for detecting H₂S, Cys, and GSH simultaneously in tumors

Key Points

Implication

Abstract

Discussion

Cite This Study

A mitochondria-targeted near-infrared fluorescent probe for detecting H₂S, Cys, and GSH simultaneously in tumors

Key Points

Implication

Abstract

Discussion

Cite This Study

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