Phytochemical Screening, Formulation and Evaluation of Leaf Extract of Leucas aspera and Leucas indica by Using Analytical Methods

The present study focuses on the formulation and evaluation of herbal tablets using the dried leaf powder of Leucas aspera and Leucas indica, two medicinal plants known for their antimicrobial, anti-inflammatory, and antioxidant properties. Three tablet formulations (F1, F2, and F3) were prepared using the wet granulation method, incorporating different binding agents—1% sodium alginate (F1), 1% acacia (F2), and 1% HPMC-10 (F3). The prepared tablets were subjected to various physicochemical evaluation parameters including general appearance, weight variation, hardness, thickness, friability, and disintegration time. All formulations exhibited acceptable physical characteristics within pharmacopeial limits. F1 showed the fastest disintegration time (4.5 minutes), indicating suitability for immediate-release formulations. F2 demonstrated balanced properties with moderate disintegration (6.2 minutes) and good mechanical strength. F3 had the highest hardness and lowest friability, but exhibited delayed disintegration (7.0 minutes), suggesting potential for sustained-release applications. This study highlights the influence of different binding agents on tablet performance and demonstrates the feasibility of developing standardized herbal tablets from Leucas species. Further studies on in-vitro drug release, stability, and pharmacological activity are recommended to validate their therapeutic potential.