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This is a Literature Review study.

Structural and temporal dynamics analysis of PD-1/PD-L1 immunotherapy in hepatocellular carcinoma: History, research hotspots, and emerging trends

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Bibliometric analysis reveals emerging trends and key research areas in PD-1/PD-L1 immunotherapy for hepatocellular carcinoma.

In the last two decades, the number of publications on PD-1/PD-L1 immunotherapy for hepatocellular carcinoma increased significantly, indicating a growing interest in this field.
A total of 2804 studies on PD-1/PD-L1 immunotherapy for HCC have been identified, contributing to significant international collaboration among researchers.
Cluster analysis highlighted five emerging subfields, including immune escape and prognostic models, pointing to diverse research directions in the treatment landscape.
This research sheds light on historical trends and research hotspots, suggesting valuable insights for future exploration in PD-1/PD-L1 immunotherapy.

Tuergan et al. (2025) studied this question.

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