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August 17, 2025CureusOpen Access

Comparative Efficacy and Tolerability of Tirzepatide Versus Semaglutide at Varying Doses for Weight Loss in Non-diabetic Adults With Obesity: A Network Meta-Analysis of Randomized Controlled Trials

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Authors

AKAlousious KasaggaDRDelvy RebellowTHTooba Hashmi

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Overview

Network meta-analysis compares tirzepatide and semaglutide for weight reduction in non-diabetic adults, indicating varying doses influence outcomes.

Key Points

  • Tirzepatide at maximum tolerated dose showed the greatest weight loss effect, achieving an average reduction of nearly 21%.
  • In total, eight randomized controlled trials with 7,179 participants assessed weight changes, waist circumference, and tolerability.
  • Weight loss efficacy was significant across all active treatments compared to placebo, with clear dose-dependent effects evident.
  • High rates of gastrointestinal side effects and treatment discontinuation were noted, especially with higher doses of semaglutide and tirzepatide.

Cite This Study

Kasagga et al. (2025) studied this question.

synapsesocial.com/papers/68af453aad7bf08b1ead293bhttps://doi.org/10.7759/cureus.90335
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Who Wins the Battle Against Obesity? A Network Meta‐Analysis Comparing Tirzepatide and Semaglutide2026 · 5 citations
  2. 2Analysis of the efficacy and safety of liraglutide, semaglutide, and tirzepatide for the treatment of overweight and obesity: a systematic review and network meta-analysis2026
  3. 3Comparative Efficacy and Safety of Tirzepatide Versus Semaglutide for Obesity: A Systematic Review2026
  4. 4Comparative Efficacy of Tirzepatide vs. Semaglutide in Reducing Body Weight in Humans: A Systematic Review and Meta-Analysis of Clinical Trials and Real-World Data2025 · 15 citations
  5. 5Comparison of Clinical Efficacy and Safety of Tirzepatide, Liraglutide and Semaglutide in Patients with Obesity and Without T2D: A Bayesian Network Meta-Analysis of Randomised Controlled Trials2026 · 2 citations