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August 18, 2025Frontiers in OncologyOpen Access

Human papillomavirus, human immunodeficiency virus, and esophageal squamous cell carcinoma in South Africa: a study of prevalence, co-infection, and risk factors

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High-risk HPV DNA is detected in 56.4% of esophageal squamous cell carcinoma cases, highlighting significant prevalence.
Co-infection was found in 23.1% of patients with both HIV and HPV, making it a critical area for further study.
Statistical analysis with chi-square tests and logistic regression showed no significant association between HIV and HPV status in ESCC patients.
Given South Africa's burden of HIV and HPV, larger multicenter studies are essential to understand their contributions to esophageal cancer.

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Analysis shows high-risk HPV prevalence in esophageal squamous cell carcinoma patients with co-infection risk, suggesting further research is needed.

Mbatha et al. (2025) studied this question.

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Analysis shows high-risk HPV prevalence in esophageal squamous cell carcinoma patients with co-infection risk, suggesting further research is needed.