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August 18, 2025International Journal of Ophthalmology

Comparative efficacy of non-steroidal anti-inflammatory drugs in preventing postoperative macular edema following cataract surgery: a systematic review and Network Meta-analysis

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Authors

MLMin LangXLXue LiMLMingming Liu

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Overview

Systematic review ranks NSAIDs for preventing postoperative macular edema in cataract surgery patients, suggesting efficacy variations.

Key Points

  • Nepafenac ranked as the most effective NSAID for preventing postoperative macular edema after cataract surgery, indicating clinical significance.
  • Analysis of 9 RCTs showed nepafenac had the highest efficacy followed by other NSAIDs, highlighting important treatment options.
  • Network meta-analysis utilized R software for data synthesis; substantial heterogeneity indicated among included studies.
  • Further high-quality RCTs are needed to affirm these findings and explore variability sources in NSAID efficacy.

Cite This Study

Lang et al. (2025) studied this question.

synapsesocial.com/papers/68af453aad7bf08b1ead2a28https://doi.org/10.18240/ijo.2025.09.15
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Annual trends of ophthalmic surgeries in Japan’s super-aged society, 2014–2020: a national claims database study2023 · 10 citations
  2. 2Topical NSAIDs impact on macular oedema and visual outcome after phacoemulsification: systematic review of RCTs with network meta-analysis2024 · 6 citations
  3. 3Anti-inflammatory Medication of Cataract Surgery in Pseudoexfoliation Syndrome – NSAID Is Needed2019 · 12 citations
  4. 4Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial2017 · 30 citations
  5. 5Complications of manual small-incision cataract surgery2022 · 21 citations