August 16, 2025JEADV Clinical PracticeOpen Access

Applicability of Novel Laser Scanning Microscopy Techniques in Demonstrating Characteristic Features of Porokeratosis: In Vivo and Ex Vivo Investigation

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Investigative analysis compares laser microscopy with traditional methods for skin cancer diagnosis in porokeratosis.

Laser microscopy techniques accurately identify cornoid lamella in porokeratosis, distinguishing it from controls.
Reflectance confocal microscopy and multiphoton microscopy show potential in diagnosing skin cancer-related porokeratosis.
Patient evaluations included clinical, dermoscopic, and imaging assessments, followed by routine histopathology for comparison.
Advanced imaging methods may reduce invasive procedures like biopsies, though mastering these techniques requires specialized training.

Inci et al. (2025) studied this question.

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