Enhancement of Solubility of Drug Acetazolamide by Different Techniques and Comparison Thereof

Solubility enhancement has attracted considerable interest as an efficient mean of improving the solubility and hence bioavailability of poorly water soluble drugs. Oral route is most of the preferred route of drug administration but it presents a considerable challenge in case of poorly soluble drugs. In the present work the solubility of Acetazolamide was enhanced using two different techniques. In which solid dispersion of Acetazolamide is prepared by physical mixture method and by kneading method using PEG-6000 and PVP K-30 as a carrier for solid dispersion and Complex is prepared by physical mixture method and kneading method using β-Cyclodextrin as a complex forming agent. Comparison different formulation is done in term of solubility and the results revealed that solid dispersion physical mixture of Acetazolamide and PEG-6000 (1:1 ratio) shows high saturation of solubility as compare to others, which leads to increase in the rate of solubility. Formulation with maximum solubility was analyzed using FT-IR, XRD and DSC studies. Thus, increases the dissolution and bioavailability of poorly soluble drug acetazolamide.