Enhancement of Solubility of Drug Acetazolamide by Different Techniques and Comparison Thereof

View Full Paper

Ask AI

Bookmark

Authors

Discussion

This analysis compares techniques to enhance solubility of acetazolamide in poorly soluble drugs, indicating solid dispersion is most effective.

Solid dispersion of acetazolamide with PEG-6000 increases solubility significantly, enhancing bioavailability.
The highest saturation of solubility was achieved using a 1:1 physical mixture with PEG-6000 over other methods.
Experimental analysis was performed using FT-IR, XRD, and DSC to confirm solubility improvement findings.
Enhancing solubility is crucial for effective oral administration of poorly soluble drugs, like acetazolamide.

Sharma et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

View Full Paper

Ask AI

Bookmark

Authors

This analysis compares techniques to enhance solubility of acetazolamide in poorly soluble drugs, indicating solid dispersion is most effective.

Solid dispersion of acetazolamide with PEG-6000 increases solubility significantly, enhancing bioavailability.
The highest saturation of solubility was achieved using a 1:1 physical mixture with PEG-6000 over other methods.
Experimental analysis was performed using FT-IR, XRD, and DSC to confirm solubility improvement findings.
Enhancing solubility is crucial for effective oral administration of poorly soluble drugs, like acetazolamide.

Sharma et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark