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August 18, 2025Open Access

Metatranscriptomic Insights into Host-Microbiome Interactions Underlying Asymptomatic COVID-19 Cases

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Authors

SCSanjana Fatema ChowdhuryBangladesh Council of Scientific and Industrial ResearchMSMd. Murshed Hasan SarkarBangladesh Council of Scientific and Industrial ResearchSSSyed Muktadir Al SiumBangladesh Council of Scientific and Industrial Research

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Overview

Observational analysis discovered altered gene expression and inflammation in asymptomatic COVID-19 patients, suggesting diverse microbiome interactions.

Key Points

  • Asymptomatic COVID-19 cases showed higher levels of multidrug resistant bacteria compared to healthy patients, indicating potential immunity factors.
  • The study revealed that TLR-4 expression was lower in asymptomatic cases, possibly affecting immune response effectiveness against COVID-19.
  • Metatranscriptomic sequencing analyzed RNA from forty nasopharyngeal samples, exploring host-microbiome dynamics and gene activity.
  • Research highlights the need for deeper examinations of how microbial interactions influence COVID-19 severity and immune reactions.

Cite This Study

Chowdhury et al. (2025) studied this question.

synapsesocial.com/papers/68af4546ad7bf08b1ead301ahttps://doi.org/10.1101/2025.08.18.670804
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metatranscriptomic insights into host-microbiome interactions underlying asymptomatic COVID-19 cases2026
  2. 2Metagenomic next-generation sequencing of nasopharyngeal microbiota in COVID-19 patients with different disease severities2024 · 3 citations
  3. 3Microbiome–Metabolome Crosstalk as a Driver of COVID-19 Severity2026
  4. 4High-resolution multi-omics defines respiratory microbiome and host signatures of COVID-19 severity2026
  5. 5Multiomics Analysis Identifies Microbiota, Immune and Metabolomics Changes Across Disease Stages of COVID-19: A Retrospective Study2026