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August 19, 2025Open Access

Supplementary Figure S1 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size

Jun Li Zoe Welham Benita Tse Chahaya Gauci Shila Ghazanfar Pratibha Panwar Alexander Engel Mark P. Molloy

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Key Points

The mutational analysis reveals high-risk oncogenic drivers independent of polyp size, indicating a subgroup with distinct characteristics.
Specifically, concurrent oncogenic drivers were identified in low-grade bowel polyps, emphasizing the need for tailored monitoring.
Assessment of early bowel polyps was conducted through detailed mutational analysis, shedding light on their complex biology.
These findings may enhance the understanding of polyp progression and risk assessment in colorectal cancer.

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Implication

Analysis identifies concurrent high-risk oncogenic drivers in early bowel polyps, suggesting new risk profiles.

Abstract

Study recruitment and analysis workflow.

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af454cad7bf08b1ead3483 https://doi.org/10.1158/2767-9764.29939599

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S4 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
2Table 1 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
3Supplementary Figure S3 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
4Supplementary Figure S9 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
5Supplementary Figure S5 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025