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August 19, 2025Open Access

Supplementary Figure S4 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size

Jun Li Zoe Welham Benita Tse Chahaya Gauci Shila Ghazanfar Pratibha Panwar Alexander Engel Mark P. Molloy

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Key Points

A subgroup of low-grade bowel polyps shows high-risk oncogenic drivers, indicating a need for further surveillance.
Key evidence includes the identification of distinct adenocarcinoma specimens and concurrent mutations in polyps.
Observational analysis of mutational data demonstrates the presence of oncogenic drivers independent of polyp size.
This highlights the importance of mutation profiling in early-stage bowel polyps for personalized treatment strategies.

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Implication

Observational analysis reveals high-risk oncogenic drivers in bowel polyps, suggesting targeted monitoring.

Abstract

Oncoplots of bowel polyps and five adenocarcinoma specimens.

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af4953ad7bf08b1ead51c2 https://doi.org/10.1158/2767-9764.29939584

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S3 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
2Supplementary Figure S1 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
3Supplementary Figure S5 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
4Supplementary Figure S9 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025
5Supplementary Figure S8 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size2025