Supplementary Figure S8 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size

Jun Li; Zoe Welham; Benita Tse; Chahaya Gauci; Shila Ghazanfar; Pratibha Panwar; Alexander Engel; Mark P. Molloy

doi:10.1158/2767-9764.29939572

August 19, 2025Open Access

Supplementary Figure S8 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size

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Key Points

No significant difference was observed in mutational burden between large and small polyps, indicating uniformity in risk.
The study categorizes polyp types as tubular adenomas, tubulovillous adenomas, and sessile serrated lesions, providing clarity on classification.
Analysis utilized the Mann-Whitney U test to assess mutational differences across polyp sizes, focusing on neoplasia risk.
Findings highlight the presence of concurrent high-risk oncogenic drivers, implying targeted approaches for management may be necessary.

Implication

Mutational analysis identifies high-risk oncogenic drivers in low-grade bowel polyps, suggesting independent risk factors exist.

Abstract

Mutational burden in different bowel neoplasia. Mann-Whitney U test comparison shows no significance between large and small polyps in the groups of tubular adenomas (TA), tubulovillous adenoma (TVA) and sessile serrated lesions (SSL).

Discussion

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af4953ad7bf08b1ead527a https://doi.org/10.1158/2767-9764.29939572

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Supplementary Figure S8 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S8 from Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size

Key Points

Implication

Abstract

Discussion

Cite This Study

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