Synthesis of a macrocyclic and medium-sized ring lactam library using cascade ring expansion reactions

Serap Yilmaz; Haimei Zhou; Çağrı Özsan; Angelo Frei; Peter O’Brien; William P. Unsworth

doi:10.1039/d5ob01048a

January 1, 2025Organic & Biomolecular ChemistryOpen Access

Synthesis of a macrocyclic and medium-sized ring lactam library using cascade ring expansion reactions

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Key Points

This approach allows for the creation of a diverse library of lactams, expanding options in synthetic chemistry.
The synthesis utilizes up to three sequential synthetic steps to achieve ring expansion reactions effectively.
Cascade ring expansion reactions are employed, highlighting a novel strategy for constructing medium-sized rings efficiently.
This methodology supports advancements in the field, potentially impacting medicinal chemistry and drug development.

Implication

This synthesis method generates a diverse library of macrocyclic lactams using sequential ring expansion reactions, indicating new pathways for chemical research.

Abstract

A versatile approach for the synthesis of a diverse library of macrocyclic and medium-sized ring lactams is described. Up to three-sequential synthetic steps were used, starting with a conjugate addition/ring...

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Cite This Study

Yilmaz et al. (2025) studied this question.

synapsesocial.com/papers/68af454cad7bf08b1ead34d7 https://doi.org/10.1039/d5ob01048a

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Synthesis of a macrocyclic and medium-sized ring lactam library using cascade ring expansion reactions

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of a macrocyclic and medium-sized ring lactam library using cascade ring expansion reactions

Key Points

Implication

Abstract

Discussion

Cite This Study

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