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August 19, 2025BMC PsychiatryOpen Access

Reduced threat-safety discrimination and generally enhanced generalization responses in adversity exposed youth with emerging psychiatric symptoms

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Authors

ZQZhiling QiaoVIB-KU Leuven Center for Brain & Disease ResearchCSCeline SamaeyVIB-KU Leuven Center for Brain & Disease ResearchLJLise JennenKU Leuven

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Implication

Adversity-exposed youth exhibit reduced threat-safety discrimination and higher risk ratings, suggesting vulnerability to psychopathology.

Key Points

  • Reduced threat-safety discrimination occurs in adversity-exposed youth, indicating altered fear processing.
  • During fear acquisition, these youths showed enhanced risk ratings for safety cues, diverging from controls.
  • Observational analysis of fear learning and generalization revealed altered responses linked to childhood adversity.
  • Findings suggest a potential vulnerability for developing more severe psychiatric disorders among youth with past adversity.

Cite This Study

Qiao et al. (2025) studied this question.

synapsesocial.com/papers/68af4551ad7bf08b1ead381chttps://doi.org/10.1186/s12888-025-07254-9
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Psychosis risk screening in different populations using the Prodromal Questionnaire: A systematic review2017 · 126 citations
  2. 2What’s the Risk? Fearful Individuals Generally Overestimate Negative Outcomes and They Dread Outcomes of Specific Events2019 · 48 citations
  3. 3Childhood adversity is associated with reduced threat‐safety discrimination and increased fear generalization in 12‐ to 16‐year‐olds2024 · 7 citations