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Immunohistochemical Expression of MLH1, PMS2 and P53 in Colorectal Carcinoma with Clinicopathologic Correlation

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MLH1 loss is significantly more frequent in tumors located in the right colon and those with T3 extension, indicating a potential classification marker.
PMS2 absence occurs mainly in moderately differentiated adenocarcinoma with clear tumor-free resection margins, highlighting its significance in tumor grading.
Immunohistochemical analysis of 102 colorectal carcinomas indicates correlations among MLH1, PMS2, and p53 expression statuses, suggesting complex relationships in tumor progression.
These findings may inform clinical decisions and prognostic evaluations, emphasizing the role of p53 and PMS2 in colorectal cancer outcomes.

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Cross-sectional analysis reveals associations between MLH1, PMS2, and p53 expressions in colorectal carcinoma, suggesting prognostic implications.

Alhamadani et al. (2025) studied this question.

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Cross-sectional analysis reveals associations between MLH1, PMS2, and p53 expressions in colorectal carcinoma, suggesting prognostic implications.