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This is a In Vitro Study study.

Highly Enantioselective Construction of Azaspiro[4.5]decane via an NHC‐catalyzed [5+1] Cycloaddition

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The method achieves high enantioselectivity, producing azaspiro[4.5]decane with 99% ee while maintaining good yields.
Results show products constructed with up to 85% yield, showcasing broad substrate compatibility.
This is the first report of N-heterocyclic carbene-catalyzed [5+1] cycloaddition for constructing these compounds.
The findings highlight potential for late-stage functionalization in diverse pharmaceutical development.

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N-heterocyclic carbene demonstrates efficient enantioselective synthesis of azaspiro[4.5]decane in diverse molecules, indicating broad applicability.

Li et al. (2025) studied this question.

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N-heterocyclic carbene demonstrates efficient enantioselective synthesis of azaspiro[4.5]decane in diverse molecules, indicating broad applicability.